Abacwaningi bathole ukuthi i-metabolite eyinhloko ye-THC ihlala inamandla ngokusekelwe kudatha evela kumamodeli wamagundane. Idatha yocwaningo olusha iphakamisa ukuthi i-THC metabolite eyinhloko ehlala emchamweni nasegazini ingase isasebenza futhi iphumelele njenge-THC, uma kungenjalo. Lokhu okutholakele okusha kuphakamisa imibuzo eminingi kunempendulo. Ngokocwaningo lwakamuva olushicilelwe ku-Journal of Pharmacology and Experimental Therapeutics, i-psychoactive metabolite ye-THC, i-11-hydroxy-THC (11-OH-THC), inamandla alinganayo noma amakhulu okusebenza kwengqondo kune-THC (Delta-9 THC).
Ucwaningo, olunesihloko esithi "I-Intoxication Equivalence of 11-Hydroxy-Delta-9-THC (11-OH-THC) Ehlobene ne-Delta-9-THC," lubonisa indlela ama-metabolites e-THC agcina ngayo umsebenzi. Kwaziwa kahle ukuthi i-THC idiliza futhi ikhiqize izinhlanganisela ezintsha ezithokozisayo lapho i-decarboxylate futhi isebenza emzimbeni womuntu. "Kulolu cwaningo, sinqume ukuthi i-metabolite eyinhloko ye-THC, i-11-OH-THC, ibonisa umsebenzi olinganayo noma omkhulu kune-THC kumodeli yomsebenzi we-cannabinoid yegundane lapho ilawulwa ngokuqondile, ngisho nokucabangela umehluko wemizila yokuphatha, ubulili, i-pharmacokinetics, kanye ne-pharmacodynamics," kusho ucwaningo. "Le datha ihlinzeka ngemininingwane ebalulekile ngomsebenzi webhayoloji wama-metabolites e-THC, yazisa ucwaningo lwe-cannabinoid lwesikhathi esizayo, futhi ibonise ukuthi ukudla kwe-THC kanye ne-metabolism kuthinta kanjani ukusetshenziswa kwensangu."
Lolu cwaningo lwenziwe ithimba laseSaskatchewan, eCanada, kuhlanganise no-Ayat Zagzoog, uKenzie Halter, u-Alayna M. Jones, uNicole Bannatyne, uJoshua Cline, u-Alexis Wilcox, u-Anna-Maria Smolyakova, noRobert B. Laprairie. Ocwaningweni, abacwaningi bajove amagundane abesilisa nge-11-hydroxy-THC futhi babona futhi bafunda imiphumela yale metabolite ye-THC uma iqhathaniswa nenhlanganisela yomzali wayo, i-Delta-9 THC.
Abacwaningi baqhubeka bephawula: "Le datha ibonisa ukuthi ekuhlolweni komsila-flick ukuze kubonwe ubuhlungu, umsebenzi we-11-OH-THC ngu-153% we-THC, futhi ekuhlolweni kwe-catalepsy, umsebenzi we-11-OH-THC ngu-78% we-THC. Ngakho-ke, ngisho nokucabangela umehluko we-pharmacokinetic obonisa i-comparable-THC noma i-comparable enkulu-THC yomzali noma i-THC11 I-THC."
Ngakho-ke, ucwaningo luphakamisa ukuthi i-THC metabolite 11-OH-THC ingadlala indima ebalulekile emsebenzini webhayoloji we-cannabis. Ukuqonda umsebenzi wayo lapho ilawulwa ngokuqondile kuzosiza ukuchaza izifundo zesikhathi esizayo zezilwane nabantu. Umbiko uveza ukuthi i-11-OH-THC ingenye yama-metabolites amabili ayisisekelo akhiwa ngemuva kokusetshenziswa kwe-cannabis, enye i-11-nor-9-carboxy-THC, engasebenzi ngokwengqondo kodwa engase ihlale egazini noma emchameni isikhathi eside.
Ngokusho kwe-US Centers for Disease Control and Prevention (CDC), ekuqaleni kwawo-1980, ukuhlolwa komchamo kwakuqondiswe ngokuyinhloko ku-11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), i-metabolite ye-Delta-9-THC, okuyisithako esiyinhloko esisebenzayo ku-cannabis.
Umbiko uveza ukuthi nakuba ukubhema insangu kuvame ukukhiqiza imiphumela ngokushesha kunokudla okudliwayo kwensangu, inani le-11-OH-THC elikhiqizwa ngokungenisa likhulu kunalelo elivela ekubhemeni izimbali zensangu. Umbiko uphakamisa ukuthi lesi ngesinye sezizathu zokuthi kungani ukudla okufakwe insangu kungase kusebenze ngokwengqondo futhi kubangele ukudideka kwabangakalungiselelwa.
I-THC Metabolites kanye nokuhlolwa kwezidakamizwa
Ubufakazi bukhombisa ukuthi i-cannabis ithinta abasebenzisi ngendlela ehlukile kuye ngomzila wokuphatha. Ucwaningo lwango-2021 olwanyatheliswa ku-Permanent Journal lubonise ukuthi imiphumela yokudliwa kwensangu mikhulu kunaleyo yokubhema insangu ngenxa ye-metabolism ye-11-OH-THC.
"I-bioavailability ye-THC ngokusebenzisa i-vaporization ingu-10% kuya ku-35%," abacwaningi babhala. "Ngemva kokumuncwa, i-THC ingena esibindini, lapho iningi laso likhishwa noma ligaywe libe yi-11-OH-THC noma i-11-COOH-THC, ne-THC esele kanye nama-metabolites ayo angena egazini. Ngokuvamile, isigamu sempilo ye-plasma ye-THC kubasebenzisi ngezikhathi ezithile siyizinsuku ezi-1 kuye kwezingu-3, kanti kubasebenzisi abangapheli, ingaba yizinsuku ezi-5 kuye kweziyi-13.
Ucwaningo lukhombisa ukuthi ngemuva kwesikhathi eside imiphumela ye-psychoactive ye-cannabis isigugile, ama-metabolites e-THC afana ne-11-OH-THC angahlala egazini nasemchamweni isikhathi eside. Lokhu kudala izinselelo zezindlela ezijwayelekile zokuhlola ukuthi abashayeli nabasubathi bakhubazekile yini ngenxa yokusebenzisa insangu. Isibonelo, abacwaningi base-Australia bebezama ukunquma isikhathi lapho i-cannabis ingase iphazamise ukusebenza kokushayela. Kwesinye isigameko, uThomas R. Arkell, uDanielle McCartney, no-Iain S. McGregor abavela kuLambert Initiative eNyuvesi yaseSydney bafunde umthelela wensangu ekhonweni lokushayela. Ithimba linqume ukuthi insangu ikhubaza ikhono lokushayela amahora ambalwa ngemva kokubhema, kodwa lokhu kuphazamiseka kuyaphela ngaphambi kokuba ama-metabolites e-THC akhishwe egazini, nama-metabolites ephikelela emzimbeni amasonto noma izinyanga.
"Iziguli ezisebenzisa imikhiqizo equkethe i-THC kufanele zigweme ukushayela kanye neminye imisebenzi ethinta ukuphepha (isb, ukusebenzisa imishini), ikakhulukazi ngesikhathi sokuqala sokwelashwa kanye namahora ambalwa ngemva komthamo ngamunye," kubhala ababhali. "Ngisho noma iziguli zingazizwa ziphazamisekile, zingase zihlolwe ukuthi zine-THC. Ngaphezu kwalokho, iziguli ze-cannabis okwamanje azikhululekile ekuhlolweni kwezidakamizwa ezihamba emgwaqweni kanye nezijeziso ezingokomthetho ezihlobene."
Lolu cwaningo olusha lwe-11-OH-THC lukhombisa ukuthi kudingeka ucwaningo olwengeziwe ukuze kuqondwe ngokujulile ukuthi ama-metabolites e-THC awuthinta kanjani umzimba womuntu. Kuphela ngemizamo eqhubekayo singakwazi ukwembula ngokugcwele izimfihlo zalezi zinhlanganisela eziyingqayizivele.
Isikhathi sokuthumela: Mar-21-2025