Abaphenyi bathole ukuthi i-metabolite eyinhloko ye-THC ihlala inamandla ngokuya ngemininingwane evela kumamodeli wegundane. Idatha yocwaningo olusha iphakamisa ukuthi ukuhlala isikhathi esiyinhloko kwe-thc metabolite kumchamo negazi kusenzeke futhi kuphumelele njenge-thc, uma kungenjalo. Lokhu kuthola okusha kuphakamisa imibuzo eminingi kunezimpendulo. Ngokusho kocwaningo lwakamuva olushicilelwe ejeni le-Pharmacology kanye nokwelapha, i-metabolite ye-phc, i-11-hydroxy-thc (11-OH-THC), ine-potency enengqondo noma enkulu kune-phc (Delta-9 thc).
Ucwaningo, olunesihloko esithi "Ukulingana ukudakwa kwe-11-hydroxy-delta-9-thc (11-oh-thc) okuhlobene neDelta-9-THC," kukhombisa ukuthi ama-thc metabolites agcina kanjani umsebenzi. Kuyaziwa ukuthi i-THC yephula futhi yakha amakhompiyutha amasha athokozisayo lapho ihlangana futhi isebenza emzimbeni womuntu. "Kulolu cwaningo, sinqume ukuthi i-metabolite eyinhloko ye-THC, 11-OH-THC, ibonisa umsebenzi olinganayo noma omkhudlwana kune-THC ephathekayo yomsebenzi we-cannabinoid uma icatshangelwa ngqo, ucansi, amakhemikhali, kanye ne-pharmacodynamics," kusho ucwaningo. "Le mininingwane ihlinzeka ngemininingwane ebalulekile emkhakheni wezinto ezibalulekile ze-thc metabolites, yazisa ukucwaninga kwe-cannabinoid yesikhathi esizayo, nemodeli yokudla kanye ne-metabolism."
Lolu cwaningo lwenziwe yiqembu elivela eSaskatchewan, eCanada, kufaka phakathi i-Ayat Zagzoog, uKenzie Halter, u-Alayna M. Jones, uJoshua Bilcox, no-Anna-Maria Smolyairie. Esivivinyweni, abacwaningi bafaka amagundane abesilisa abane-11-hydroxy-thc baphawula futhi bafunda imiphumela yalesi simo se-thc metabolite uma siqhathaniswa nesamba sabo somzali, Delta-9 thc.
Abaphenyi baphinde baphawula: "Le mininingwane ikhombisa ukuthi ekuhlolweni komsila wokuhlola izinhlungu, umsebenzi we-11-oh-Thc ngu-78% lowo thc.
Ngakho-ke, ucwaningo lubonisa ukuthi i-THC Metabolite 11-OH-THC ingadlala indima ebalulekile emsebenzini webhayoloji weCannabis. Ukuqonda umsebenzi wayo lapho kuphathwe ngqo kuzosiza ukuchaza izifundo zezilwane ezizayo nezintu. Umbiko ukhuluma ngokuthi u-11-OH-THC ungomunye walezi zinto ezimbili eziyisisekelo ezakhiwe ngemuva kokusetshenziswa kwe-cannabis ngemuva kokusetshenziswa kwe-cannabis, enye ibe ngu-11-noma-9-carcoboxy-thc, okungeyona igazi noma umchamo isikhathi eside.
Ngokusho kwezikhungo zase-US zokulawulwa kwezifo kanye nokuvimbela (CDC), ekuqaleni kuka-1980, ukuhlolwa komchamo ngokuyinhloko kubhekiswe ku-11-9-carboxy-thc), i-metabolite ye-Delta-9-THC, okuyisithako esikhulu esisebenzayo ku-cannabis.
Umbiko uveza ukuthi yize ukubhema i-cannabis kuvame ukukhiqiza imiphumela ngokushesha kunokudla ama-cannabis edibles, inani le-11-oh-thc elikhiqizwa ngokufakwa likhulu kunalokho kusuka kuzimbali ze-cannabis. Lo mbiko uphakamisa ukuthi lesi ngesinye sezizathu ezenza ukuthi ukudla okufakwe insangu kungaba yi-psychoactive futhi kubangele ukudideka okungakulungele.
I-THC Metabolites kanye nokuhlolwa kwezidakamizwa
Ubufakazi bukhombisa ukuthi i-cannabis ithinta abasebenzisi ngendlela ehlukile ngokuya ngendlela yokuphatha. Ucwaningo lwe-2021 olushicilelwe e-Realthent Journal luveze ukuthi imiphumela yokudla ama-cannabis edibles inkulu kune-cannabis ebhemayo ngenxa yemetabolism ka-11-oh-thc.
"I-BioavaAbility ye-THC nge-Vaporization ingu-10% kuya ku-35%," kubhalwe abaphenyi. "Ngemuva kokutholwa, i-THC ingena esibindini, lapho iningi lawo liqedwa noma lihlanjululwe libe yi-11-oh-Thc noma i-thc esele kuphela, i-thc ingena kuma-lipophility amafutha kuphela. I-THC ingena ngokushesha, ngokuvamile, I-Plasma Half-Life of Thc kubasebenzisi ngezikhathi ezithile yizinsuku ezi-1 kuye kwezi-3, ngenkathi kubasebenzisi abangalapheki, ingaba yize izinsuku ezi-5 kuye kwezingu-13. "
Ucwaningo lukhombisa ukuthi isikhathi eside ngemuva kokudla kwemiphumela ye-cannabis ye-cannabis, i-thc metabolites efana ne-11-oh-thc ingahlala egazini kanye nomchamo wezikhathi ezeluliwe. Lokhu kubeka izinselelo zezindlela ezijwayelekile zokuhlola ukuthi abashayeli nabasubathi bakhubazekile ngenxa yokusetshenziswa kwe-cannabis. Isibonelo, abacwaningi base-Australia bebelokhu bezama ukunquma isikhathi ngesikhathi se-cannabis bangaphazamisa ukusebenza kokushayela. Kokunye, uThomas R. Arkell, uDanielle McCartney, no-Iain S. McGregor kusuka ku-Lambert isinyathelo eNyuvesi yaseSydney bafunda umthelela we-cannabis ngekhono lokushayela. Iqembu linqume ukuthi i-cannabis ilimaza amandla okushayela amahora amaningi ngemuva kokubhema, kepha lokhu kulimazeka kuphela ngaphambi kokuba kususwe ama-metabolites we-thc egazini, ahlala e-Metabolites emzimbeni amasonto noma izinyanga.
"Iziguli zisebenzisa imikhiqizo equkethe i-THC kufanele zigweme ukushayela kanye neminye imisebenzi ebucayi bokuphepha (isib. Imishini yokusebenza), ikakhulukazi ngesikhathi sokwelashwa kokuqala kanye namahora ambalwa ngemuva komthamo ngamunye," kusho ababhali. "Noma ngabe iziguli zingazizwa zikhubazekile, zingase zihlole ukuthi zinezinzuzo ze-THC.
Lolu cwaningo olusha ngo-11-OH-THC lubonisa ukuthi kudingeka izifundo eziningi ukuze ziqonde kakhulu ukuthi i-Thc Metabolites ithinta kanjani umzimba womuntu. Kuphela ngemizamo eqhubekayo esingathola ngokugcwele izimfihlo zalezi zinhlaka ezihlukile.
Isikhathi sePosi: Mar-21-2025