I-THC, i-CBD, ama-cannabinoids, imiphumela ye-psychoactive - kungenzeka ukuthi uzwe okungenani ama-ambalwa la magama uma ngabe uzama ukuqonda i-THC, i-CBD, kanye nokwehluka phakathi kwabo. Mhlawumbe uke wahlangabezana nohlelo lwe-endocannaninoid, ama-cannabinoid receptors, kanye nama-terpenes. Kepha konke kuvela ngempela?
Uma ufuna indlela yokuqonda ukuthi kungani imikhiqizo ye-THC ikutholela imikhiqizo ephezulu ne-CBD futhi yini okufanele yenziwe ngama-endocannabinoids, wamukelekile, usendaweni efanele.
Ama-cannabinoids kanye neqhaza le-ECS
Ukuqonda i-THC vs CBD nokuthi zisithinta kanjani, okokuqala kudingeka uqonde uhlelo lwe-endoncaninoid (ECS), olusiza umzimba ukugcina ama-molecule asebenzayo ngezinto zawo ezintathu eziphambili: noma ama-endocanbabinoids, imizimba yethu ikhiqiza; ama-receptors la ma-molekyuli abopha; nama-enzyme awephula.
Ubuhlungu, ukucindezelwa, isifiso, i-metabolism yamandla, umsebenzi we-cardiovascular, umvuzo kanye nokugqugquzelwa, ukuzala kabusha, nokulala kuyimisebenzi emincane nje yomzimba otholwa yi-ECS. Izinzuzo ezingaba khona zezempilo ze-cannabinoids ziningi futhi zifaka ukuncishiswa kokuvuvukala kanye nokulawulwa kwe-nausea.
Yini i-thc eyenzayo
I-cannabinoid eningi kakhulu futhi eyaziwayo etholakala kwi-cannabis plant yi-tetrahyrocaninol (thc). Isebenza i-CB1 Receptor, isakhi se-ECS ebuchosheni obuqondisa ukudakwa. Ukudakwa kwe-THC kukhonjisiwe ukukhulisa ukugeleza kwegazi ku-cortex esemqabile, isifunda sobuchopho esibhekele ukwenziwa izinqumo, ukunakwa, amakhono ezimoto, kanye neminye imisebenzi ephethe. Uhlobo ngqo lwemiphumela ye-THC kule misebenzi iyahlukahluka kuye ngomuntu.
Lapho i-THC ibopha ama-CB1 receptors, nayo ibangela imizwa ye-euphoria kusuka ohlelweni lomvuzo lweBrain. I-Cannabis isebenze indlela yomvuzo yeBrain's Umvuzo, osenza sizizwe sihle, futhi sandisa amathuba ethu okuphinda ahlanganyele esikhathini esizayo. Umphumela we-THC ohlelweni lomvuzo wobuchopho luyinto enkulu emandleni e-cannabis ukukhiqiza imizwa yokudakwa kanye ne-euphoria.
Yini i-CBD eyenzayo
I-THC ikude nokuphela kwesithako ku-cannabis enomthelela oqondile emsebenzini wobuchopho. Ukuqhathanisa okuphawuleka kakhulu kungcono kakhulu nge-cannabidiol (CBD), okuyi-cannabinoid yesibili etholakala esitshalweni se-cannabis. I-CBD ivame ukuthathwa njenge-non-psychoactive kepha lokhu kuyadukisa kusukela noma iyiphi into enomphumela oqondile emsebenzini wobuchopho inengqondo. I-CBD ngokuqinisekile idala imiphumela ye-psychoactive uma ixhumana nobuchopho kanye nohlelo lwezinzwa oluphakathi, njengoba kubikwa ukuthi inamandla amakhulu okuhlaselwa kanye nokulwa nokukhathazeka.
Ngakho-ke ngenkathi i-CBD inengqondo ngempela, ayidakwanga. Okungukuthi, akukutholi phezulu. Lokho kungenxa yokuthi i-CBD imbi kakhulu ekusebenzeni kwe-CB1 receptor. Eqinisweni, ubufakazi bubonisa ukuthi empeleni buphazamisa umsebenzi we-CB1 Receptor, ikakhulukazi lapho kukhona i-THC. Lapho i-THC ne-CBD zisebenza ngokubambisana ukuthinta umsebenzi we-CB1 Receptor, abasebenzisi bavame ukuzizwa benobuhlakani obuningi, abanciphile futhi babe nethuba eliphansi kakhulu lokuthola i-paranoia uma kuqhathaniswa nemiphumela enomuzwa lapho i-CBD ingekho. Lokho kungenxa yokuthi i-THC isebenze i-CB1 receptor, kuyilapho i-CBD ivimbela khona.
I-CBD ne-THC ehlangana kanjani nomunye
Beka umane, i-CBD ingavikele ekulimazekeni kwengqondo okuhlotshaniswa nokweqile kwe-thc. Ucwaningo lwango-2013 olushicilelwe kwiphephabhuku lwe-Pysychopharmacology luphethwe abahlanganyeli futhi bathola ukuthi labo abanikezwe i-CBD ngaphambi kokuphathwa kwenkumbulo kuneziguli - okukhombisa ukuthi i-CBD ingahle inciphise ukusilela kokuqonda kwengqondo.
Eqinisweni, ukubuyekezwa ngo-2013 kwezifundo ezicishe zibe ngu-1,300 ezishicilelwe kumaphephabhuku wesayensi zithola ukuthi "i-CBD ingamelana nemiphumela emibi ye-THC." Ukubuyekezwa kukhombisa nesidingo socwaningo oluthe xaxa kanye nokubheka imiphumela ye-CBD ekusetshenzisweni kwe-THC ezimweni zangempela zomhlaba. Kepha idatha ekhona icacile ngokwanele ukuthi i-CBD ivame ukunconywa njenge-antidote yalabo abadle ngokweqile i-THC futhi bazithole bekhungathekile.
ICannabinoids Ixhumana nezinhlelo eziningi emzimbeni
I-THC ne-CBD BIND kwezinye izihlokwana eziningana emzimbeni. Isibonelo, i-CBD, okungenani inezindawo eziyi-12 zesenzo ebuchosheni. Futhi lapho i-CBD ingalinganisa imiphumela ye-THC ngokuvimbela ama-CB1 Reseptors, ingahle ibe neminye imiphumela ku-thc metabolism kumasayithi ahlukene ezenzo.
Ngenxa yalokhu, i-CBD kungenzeka ingavimbi njalo noma ilinganise imiphumela ye-THC. Kungabuye kube ngcono ngokuqondile izinzuzo ezinhle zezokwelapha ze-THC. Isibonelo, i-CBD, ngokwesibonelo, ithuthukise impumuzo yobuhlungu be-thc. I-THC kungenzeka bobabili i-anti-inflammatoper ne-neuroprotictic antioxidant, ikakhulukazi ngenxa yokwenziwa kwayo kwama-CB1 receptors endaweni elawulwa yibuhlungu yobuchopho.
Ucwaningo lwango-2012 lwembula ukuthi i-CBD ixhumana ne-Alpha-3 (α3) Glycine Receptors, ithagethi elibalulekile lokucubungula izinhlungu emgogodleni, ukucindezela ubuhlungu obungamahlalakhona nokuvuvukala. Kuyisibonelo salokho okubizwa ngokuthi yi-Enlouna umphumela, lapho amakhompiyutha ehlukene we-cannabis asebenza ndawonye wonke ukukhiqiza umphumela omkhulu kunokuba kudliwe ngokwehlukana.
Kepha ngisho nalokhu kuhlangana akucaci ngokuphelele. Ngomhlaka 2019 Ucwaningo, abacwaningi bathola ukuthi imithamo ephansi ye-CBD empeleni ithuthukise imiphumela edakayo ye-THC, kanti imithamo ephezulu ye-CBD yanciphisa imiphumela edakayo ye-THC.
Ama-terpenes kanye nomphumela wokuhlonza
Kungenzeka ngokuphelele ukuthi eminye yemiphumela emibi eyaziwayo ye-cannabis (efana nokukhiya kombhede) ingahle ibe nokuncane kakhulu ukwenza nge-THC uqobo, kodwa kunalokho, iminikelo ehlobene nama-molecule amancane. Amakhemikhali amakhemikhali abizwa nge-terpene anikeza izitshalo ze-cannabis okungcono kakhulu nama-aromas. Zitholakala ezitshalweni eziningi - njenge-lavender, amagxolo esihlahla kanye nama-hops - futhi ahlinzeke ngephunga lamafutha abalulekile. Ama-Terpenes, okuyiqembu elikhulu kunawo wonke ama-phytochecicals owaziwayo e-cannabis, afakazele futhi ukuba yingxenye ebucayi yomphumela wokuhlonza. Hhayi nje kuphela ukuthi ama-terpenes anikeza insangu ukunambitheka okuhlukile nephunga, kepha abonakala nasekuxhaseni amanye ama-molecule e-cannabis ekukhiqizeni imiphumela ngokomzimba nangobuciko.
Umunyu ongaphansi
I-Cannabis isitshalo esiyinkimbinkimbi enocwaningo oluncane olutholakala emiphumeleni yalo ekusebenzeni kanye nokusebenzisana nomzimba womuntu - futhi siqala nje ukufunda izindlela eziningi thc, i-CBD, nezinye ezinye izinkwa ze-cannabis zisebenza ndawonye futhi zisebenzisana ne-ECS yethu ukuthi zishintshe indlela esizwa ngayo.
Isikhathi Sokuthumela: Oct-19-2021