I-THC, i-CBD, ama-cannabinoids, imiphumela ye-psychoactive - kungenzeka ukuthi uzwile okungenani ambalwa alawa magama uma uzama ukuqonda i-THC, i-CBD, kanye nomehluko phakathi kwawo.Mhlawumbe uhlangabezane nohlelo lwe-endocannabinoid, ama-cannabinoid receptors, kanye nama-terpenes.Kodwa kumayelana nani ngempela?
Uma ufuna indlela yokuqonda ukuthi kungani imikhiqizo ye-THC ikwenza uphakame futhi imikhiqizo ye-CBD ayikwenzi nokuthi yini okumele iyenze ngama-endocannabinoids, wamukelekile, usendaweni efanele.
Ama-Cannabinoids kanye nendima ye-ECS
Ukuze uqonde i-THC vs CBD nokuthi zisithinta kanjani, okokuqala udinga ukuqonda uhlelo lwe-endocannabinoid (ECS), olusiza umzimba ukugcina ibhalansi yokusebenza ngokusebenzisa izingxenye zawo ezintathu eziyinhloko: ama-molecule "esithunywa", noma i-endocannabinoids, ekhiqizwa imizimba yethu;ama-receptors la ma-molecule abopha kuwo;kanye nama-enzyme awadiliza.
Ubuhlungu, ukucindezeleka, isifiso sokudla, amandla e-metabolism, ukusebenza kwenhliziyo nemithambo yegazi, umvuzo kanye nogqozi, ukukhiqiza kabusha, nokulala kumane kuyimisebenzi embalwa yomzimba enomthelela wama-cannabinoids ngokusebenza ku-ECS.Izinzuzo zezempilo ezingaba khona zama-cannabinoids ziningi futhi zihlanganisa ukunciphisa ukuvuvukala nokulawula isicanucanu.
Okwenziwa yiTHC
I-cannabinoid etholakala kakhulu futhi eyaziwa kakhulu esitshalweni se-cannabis yi-tetrahydrocannabinol (THC).Ivula i-CB1 receptor, ingxenye ye-ECS ebuchosheni elawula ukudakwa.Ukudakwa kwe-THC kukhonjisiwe ukwandisa ukugeleza kwegazi ku-prefrontal cortex, isifunda sobuchopho esibhekene nokuthatha izinqumo, ukunaka, amakhono emoto, neminye imisebenzi yokuphatha.Ubunjalo obuqondile bemiphumela ye-THC kule misebenzi iyehluka kumuntu nomuntu.
Uma i-THC ibophezela kuma-receptors e-CB1, iphinda ibangele imizwa yenjabulo evela ohlelweni lomvuzo lobuchopho.ICannabis ivula indlela yomvuzo yobuchopho, esenza sizizwe sijabule, futhi yandisa amathuba ethu okuphinda sihlanganyele esikhathini esizayo.Umthelela we-THC ohlelweni lomvuzo lobuchopho uyisici esikhulu emandleni ensangu okukhiqiza imizwa yokudakwa kanye nenjabulo.
Okwenziwa yi-CBD
I-THC ikude kakhulu nesithako se-cannabis esinomthelela oqondile ekusebenzeni kobuchopho.Ukuqhathanisa okuphawuleka kakhulu nge-cannabidiol (CBD), okungeyesibili i-cannabinoid etholakala esitshalweni sensangu.I-CBD ivame ukubizwa ngokuthi ayisebenzi ngokwengqondo kodwa lokhu kuyadukisa ngoba noma iyiphi into enomthelela oqondile ekusebenzeni kobuchopho isebenza ngokwengqondo.I-CBD ngokuqinisekile idala imiphumela ye-psychoactive lapho ixhumana nobuchopho kanye nesistimu yezinzwa emaphakathi, njengoba kubikwa ukuthi inezindawo ezinamandla kakhulu zokulwa nokuthunjwa kanye nokulwa nokukhathazeka.
Ngakho-ke ngenkathi i-CBD isebenza ngokwengqondo, ayidaki.Okungukuthi, akukukhulisi.Lokho kungenxa yokuthi i-CBD yimbi kakhulu ekusebenziseni i-CB1 receptor.Eqinisweni, ubufakazi buphakamisa ukuthi empeleni kuphazamisa umsebenzi we-CB1 receptor, ikakhulukazi ebukhoneni be-THC.Lapho i-THC ne-CBD zisebenza ndawonye ukuze zithinte umsebenzi wama-receptor we-CB1, abasebenzisi bavame ukuzwa ukuphakama okuthambile, okuguquguqukayo futhi babe nethuba eliphansi kakhulu lokuba ne-paranoia uma kuqhathaniswa nemiphumela ezwakalayo lapho i-CBD ingekho.Lokho kungenxa yokuthi i-THC yenza i-CB1 receptor isebenze, kuyilapho i-CBD iyivimbela.
I-CBD ne-THC zisebenzisana kanjani
Kalula nje, i-CBD ingavikela ekulimaleni kwengqondo okuhlobene nokuchayeka ngokweqile ku-THC.Ucwaningo lwango-2013 olwanyatheliswa kuyi-Journal of Psychopharmacology lwanikeza i-THC kubahlanganyeli futhi lwathola ukuthi labo ababenikezwe i-CBD ngaphambi kokuphathwa kwe-THC babonisa ukukhubazeka okuncane kwenkumbulo ye-episodic kuneziguli ezazinikezwe i-placebo - okubonisa futhi ukuthi i-CBD ingase inqande ingqondo eyenziwe yi-THC. okushodayo.
Eqinisweni, ukubuyekezwa kuka-2013 cishe kwezifundo eziyi-1,300 ezishicilelwe emaphephandabeni esayensi kwathola ukuthi "i-CBD ingamelana nemiphumela emibi ye-THC."Ukubuyekezwa futhi kukhombisa isidingo socwaningo olwengeziwe kanye nokubheka imiphumela ye-CBD ekusetshenzisweni kwe-THC ezimeni zomhlaba wangempela.Kepha imininingwane ekhona icace ngokwanele ukuthi i-CBD ivame ukutuswa njengekhambi kulabo abadle iTHC eningi bengazi futhi bazithole sebekhungathekile.
Ama-cannabinoids asebenzisana nezinhlelo eziningi emzimbeni
I-THC ne-CBD zibophezela kwezinye izinhloso ezimbalwa emzimbeni.I-CBD, ngokwesibonelo, inezindawo okungenani eziyi-12 zesenzo ebuchosheni.Futhi lapho i-CBD ingase ilinganisele imiphumela ye-THC ngokuvimbela ama-receptors e-CB1, ingaba neminye imiphumela kumetabolism ye-THC ezindaweni ezahlukene zesenzo.
Ngenxa yalokho, i-CBD kungenzeka ingavimbeli noma ilinganisele imiphumela ye-THC ngaso sonke isikhathi.Kungase futhi kuthuthukise ngokuqondile izinzuzo zezokwelapha ezingaba khona ze-THC.I-CBD ingase, isibonelo, ithuthukise ukukhululeka kobuhlungu obubangelwa yi-THC.I-THC kungenzeka ukuthi iyi-anti-inflammatory and neuroprotective antioxidant, ikakhulukazi ngenxa yokusebenza kwayo kwama-receptors e-CB1 endaweni yokulawula izinhlungu ebuchosheni.
Ucwaningo olwenziwa ngo-2012 lwembula ukuthi i-CBD isebenzisana ne-alpha-3 (α3) glycine receptors, okuhlosiwe okubalulekile kokucubungula ubuhlungu emgogodleni, ukucindezela ubuhlungu obungapheli nokuvuvukala.Kuyisibonelo salokho okubizwa ngokuthi i-entourage effect, lapho izinhlanganisela ezahlukene ze-cannabis zisebenza ndawonye ukuze zikhiqize umthelela omkhulu kunokuba zisetshenziswe ngokuhlukana.
Kodwa nalokhu kusebenzisana akucacile ngokuphelele.Ocwaningweni lwangoFebhuwari 2019, abacwaningi bathola ukuthi imithamo ephansi ye-CBD empeleni yayithuthukisa imiphumela edakayo ye-THC, kuyilapho imithamo ephezulu ye-CBD yehlisa imiphumela edakayo ye-THC.
I-Terpenes kanye nomphumela wokugqugquzela
Kungenzeka ukuthi eminye yemiphumela emibi eyaziwa kakhulu ye-cannabis (efana ne-couch-lock) ingase ihlangane kancane ne-THC ngokwayo, kodwa kunalokho, iminikelo ehlobene yama-molecule angaziwa kancane.Izithako zamakhemikhali ezibizwa nge-terpenes zinikeza izitshalo ze-cannabis ukunambitheka kwazo okuhlukile namaphunga.Zitholakala ezitshalweni eziningi - njenge-lavender, amagxolo esihlahla, nama-hops - futhi zinikeza iphunga lamafutha abalulekile.I-Terpenes, okuyiqembu elikhulu kunawo wonke lamakhemikhali e-phytochemicals ensangu, nawo afakazele ukuthi ayingxenye ebalulekile yomphumela wokugqugquzela.I-terpenes ayigcini nje ngokunikeza insangu ukunambitheka nephunga elihlukile, kodwa futhi ibonakala isekela amanye ama-molecule e-cannabis ekukhiqizeni imiphumela ye-physiological and cerebral.
Umugqa ongezansi
I-Cannabis isitshalo esiyinkimbinkimbi esinocwaningo oluncane olutholakalayo mayelana nemiphumela yaso kanye nokusebenzisana nomzimba womuntu - futhi siqala ukufunda izindlela eziningi i-THC, CBD, nezinye izinhlanganisela ze-cannabis ezisebenza ndawonye futhi zihlanganyele ne-ECS yethu ukuze siguqule indlela esizizwa ngayo.
Isikhathi sokuthumela: Oct-19-2021